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1,3 Even in the absence of a previous heart attack or stroke, adults with type 2 diabetes face an increased risk of cardiovascular events, underscoring the need for therapies that go beyond managing blood sugar, John B

Diabetologia 37(Suppl 2):S30S35 Hugill A, Shimomura K, Ashcroft FM, Cox RD (2010) A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse

Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production ( In contrast, some postbiotics may suppress GLP-1 signaling

While we deeply respect the role of SGLT2 inhibitors like Jardiance in managing diabetes and protecting the heart, our specific focus is on helping patients achieve their weight management goals

In HF, the inadequate supply of oxygen causes the heart to take up and utilize glucose as a more efficient energy substrate 4