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In brief, data are collected retrospectively at first visit and prospectively whenever the patient returns for scheduled follow-up (at least every 3 months) or unscheduled visits with neurologists and neuro-ophthalmologists specialized in IIH
The table adds that combined gastrointestinal effects would be potentially additive and unpredictable
We therefore measured G protein-dependent cAMP generation and -arrestin-1 and -2 recruitment with exendin-4, exendin-phe1, and exendin-asp3 at two time-points to avoid kinetic artefacts 38 , and calculated the pathway bias by fitting the response data to a modified form of the operational model of agonism 39 (Fig
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