In general, most hydrophobic BAs are considered as FXR agonists, while hydrophilic non-12-OH TMCA, UDCA, and T(G)UDCA serve as endogenous FXR antagonists 4,9,10
[6] [7] If genuine pancreatic insufficiency is suspectedparticularly in patients with a history of pancreatitis, pancreatic surgery, or conditions like cystic fibrosisyour GP can arrange appropriate investigations, including faecal elastase testing (values below 200 g/g suggest exocrine pancreatic insufficiency) and referral to gastroenterology if needed
Factors that reduce the risk of weight regain include: Consistent protein intake Strength or resistance training Structured meal timing Adequate sleep Stress management Addressing insulin resistance Gradually tapering instead of stopping abruptly Regain is a biological response, not a failure
Originally developed for the treatment of type 2 diabetes, these peptide-based drugs are now at the forefront of both metabolic disease management and obesity treatment, driving unprecedented market growth and industry attention
See section 4