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In general, some people at risk of deficiency include those who have had intestinal surgery, including weight loss surgery, diseases that affect the gut, such as Crohns disease or celiac disease, and older people who eventually lose the ability to absorb vitamin B12

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GSH is capable of scavenging ROS through Nrf2-mediated heme oxygenase-1 induction and enhancing M1-like macrophage polarization regulation, showing that GSH may be a useful strategy to increase the human defense system (Mittal et al., 2014