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However, several safety considerations warrant attention

More clinical research and experiments in terms on antioxidant therapy, especially in deciding optimal drug dosages and treatment efficacy, stay pivotal for future investigations ( Above all, this review thoroughly summarizes the function of oxidative stress in periodontitis and discusses how antioxidants, by inhibiting oxidative stress, are applied in its treatment

Drugs with high first-pass effect may require alternative routes (sublingual, IV, rectal, transdermal) or higher oral doses

The site is a longstanding, government-run database of human clinical trials that are being run worldwide

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