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Masson, W

Both agents provide substantial weight reduction and improvements in glycemic control, yet they differ meaningfully in mechanism, magnitude of effect, and patient suitability

The GLP1R weight loss finding from the main study did not replicate in the UK Biobank, though the authors note that the UK Biobank group was too small to reliably detect the effect

Sanchez-Lopez D, Lestegas-Soto A, Garcia-Vega D, Vinuela JE, Reija-Lopez L, Martinez-Cereijo JM, et al

GLP-1 Receptor Agonists Related to Body Contouring Surgery The rapid and significant weight loss induced by GLP-1 RAs results in substantial depletion of subcutaneous fat and loss of skin elasticity, leading to pronounced skin laxity and body contour deformities