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marketed as Mounjaro for T2DM and Zepbound for obesity), is a 39-amino acid peptide acylated with a C20:0 fatty diacid moiety to lysine residue at position 20 with a molecular weight of 4.8 kDa [ Figure 2 , Table 1 ]
#GLP1 receptor agonists are everywhere in medicine and popular culture right now
GLP-1s are a specific type of medication first launched in 2005 for the treatment of type 2 diabetes
It's a slow path to degradation but a certain one
So they screened an enormous set of molecules for their ability to stop the new death pathway, and selected a handful that seemed to halt progress
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