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Ibuprofen (e.g., Advil, Motrin, Midol, Nurofen, Dalsi, etc.) is one of the most used non-steroidal anti-inflammatory drugs (NSAIDs) globally and is considered an essential medicine by the World Health Organization (Miranda et al., 2021

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This is of particular importance for defining the redox secretome as opposed to the proteome, given the much lower concentration of secreted proteins compared to intracellular proteins