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This process involves three main stages, namely proliferation, matrix maturation, and mineralisation, leading to the formation of bone without a prior cartilaginous phase

You Do Not have to increase to full dose if the effect is present

63 Considering that T2DM and MASLD can reciprocally cause and affect each other, and given liraglutides potential therapeutic characteristics for MASLD, which may be beneficial for anti-fibrosis, more aggressive use of higher doses may bring greater clinical benefits in some groups, such as those with higher-grade fibrosis with or without T2DM

Diabetes - GLP-1 agonists should be primarily considered in patients with type 2 diabetes with suboptimal glycaemic control despite maximal tolerated dose of metformin (+/- other agents) especially where weight loss is desired and/or significant stroke risk is present

PMID: 18061177