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ICH Harmonised Tripartite Guideline

Long-term studies are needed to assess the sustained effects of these medications on OSA outcomes and evaluate their safety profile over extended periods

For patients with obesity, type 2 diabetes, or significant metabolic syndrome, GLP-1 medications have strong evidence and meaningful clinical outcomes

4.3 Artificial intelligence (AI)-based diagnostics AI-based algorithms, trained on large datasets of retinal images, have transformed DR diagnosis by achieving over 95% accuracy in detecting NPDR and predicting its progression