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In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)

Todd JE, Mancino L, Lin BH

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The 1 mg dose of semaglutide was also more effective at reducing body weight than either of the higher doses of dulaglutide