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In the analyses based on PIONEER 2 and 3, oral semaglutide 14 mg was associated with improved clinical outcomes and increased costs from a healthcare payer perspective, yielding ICERs of GBP 11,006 and GBP 4930 per QALY gained versus empagliflozin 25 mg and sitagliptin 100 mg, respectively
In one clinical trial , participants lost 11.2% of their body weight with 15 mg of tirzepatide, compared to 5.7% of weight with 1 mg of semaglutide
Older individuals may benefit more from supplementation and potentially tolerate higher doses well
It is not known if Wegovy is safe and effective for use in children under 12 years of age
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