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In the ATTAIN program, Foundayo also led to reductions in many markers of cardiovascular risk, including waist circumference, non-HDL cholesterol, triglycerides and systolic blood pressure across all doses

4.1 Pharmacokinetic and pharmacodynamic considerations of antioxidant supplementation in AMS As mentioned above, oxidative stress has been proposed as a key contributor to the pathophysiology of AMS, driven by hypobaric hypoxiainduced mitochondrial dysfunction, increased ROS generation, endothelial activation, and neurovascular dysregulation

Nat Rev Endocrinol (2018) 14(5):27084

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