Conversely, discontinuation rates were increased to 28.1% (95% CI 27.7, 28.4) at 1 year and 43.6% (95% CI 43.2, 44.0) at 3 years when using a grace period of 60 days (ESM Table 4)
Search items included medication-related itemsGLP-1 receptor agonist, GLP-1RA, dual-agonist, and glucagon-like peptide-1 along with cardiovascular outcome-related items major adverse cardiovascular event, myocardial infarction, coronary artery disease, peripheral arterial disease, heart failure, hypertension, and atrial fibrillation. Studies were meticulously screened and included if they reported cardiovascular outcomes related to MACE, myocardial infarction (MI), CAD, PAD, HF, hypertension (HTN), or AF
Fasano, A
The safety profile compares favorably to alternatives such as NSAIDs and corticosteroids, which carry major risks with long-term use
In a murine diet-induced obesity (DIO) model, after 25 days of treatment, results demonstrated: Greater than 30% weight loss when nimacimab was combined with the dual GLP-1/GIP agonist, tirzepatide Nimacimab alone demonstrated 23.5% weight loss, comparable to monlunabant and tirzepatide alone