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SURMOUNT-3 and SURMOUNT-4 Trials (2023) In a 2023 NEJM publication , researchers reported that Retatrutide: Produced an average of 24.2% total body weight loss at 48 weeks in individuals without diabetes Patients on the highest dose lost over 58 pounds on average Outperformed all currently available GLP-1 and GIP analogs Additional findings included: Significant reduction in liver fat (up to 85%) Improved insulin sensitivity and HOMA-IR scores Reduced blood pressure, triglycerides, and inflammation markers These results are unmatched in obesity pharmacotherapy history and suggest that Retatrutide could soon set a new gold standard for metabolic treatment

Experimental studies have investigated its influence on chromatin structure, telomerase-associated activity, and intracellular signalling pathways, with observed effects dependent on concentration, exposure duration, and model system

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By matching therapies to the biological mechanisms active in each subgroup - rather than treating all patients as a homogeneous population - PrecisionLife enables far more targeted, de-risked development in secondary indications

PMC 2722857