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The body does most tissue repair during sleep, making evening dosing physiologically advantageous
Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, and Bloom SR
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Clinical Significance: These data suggest that orforglipron could provide an oral alternative to injectable GLP-1 therapies
This bioavailability gap means oral dosing requires higher amounts to achieve equivalent systemic exposure
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