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The biggest opposition was in the form of a PIL, submitted to the Delhi High Court in May 2025 by Jitendra Chouksey, fitness evangelist and founder at Pune-based preventive health company FITTR

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Clinicians should monitor patients for potential adverse effects including pancreatitis (severe, persistent abdominal pain), gallbladder disease (right upper quadrant pain), diabetic retinopathy complications (especially with rapid glucose improvement), acute kidney injury with dehydration, and hypoglycemia when combined with insulin or sulfonylureas

Many weight loss methods, including GLP-1 medications like semaglutide and retatrutide , lead to unintended loss of lean mass