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Mitochondrial Ca 2+ overload due to MCU overactivation increases Ca 2+ sensitivity, enhancing myosin light chain phosphorylation and promoting contraction, and mitochondrial ROS activate redox-sensitive pathways such as MAPK and NF-B, driving VSMC proliferation and neointima formation

doi: 10.1016/J.CURTHERES.2022.100672 128 WangFZhangYYuTHeJCuiJWangJet al