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Fasting GIP, GLP-1 and insulin were comparable in Gipr AP-KO animals and controls (Extended Data Fig

This dual-responsiveness can enhance therapeutic precision, but it also introduces challenges in terms of premature degradation and chemical instability during formulation or circulation

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Extracellular Cu 2+ binding to ceruloplasmin is reduced by the metalloreductase six-transmembrane epithelial antigen of the prostate (SETAP) to Cu + , and copper transporter 1 (CTR1) (also known as solute carrier family 31 member 1, SLC31A1) transports Cu + into cells (Ohgami et al., 2006)