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Interestingly, sulforaphane, an nrf2 activator, has been shown to limit mtROS generation and prevent both NLRP3 and NLRC4 activation in murine macrophages (Lee et al., 2016)
These complementary mechanisms suggest potential synergy
They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition
For those managing a confirmed deficiency rather than simply maintaining levels, the treatment approach shifts significantly
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