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Oral semaglutide reduced major adverse cardiovascular events by 14% compared to placebo (hazard ratio 0.86, 95% CI 0.77-0.96)
Constipation also happens, sometimes alternating with diarrhea
For neurological CNS biology research, note that Semaglutide has limited blood-brain barrier penetration relative to smaller CNS-active peptides , intracerebroventricular administration routes may be required for studies examining direct central GLP-1R biology independently of peripheral-to-central signalling mechanisms
This helps reduce irritation, prevents thickening or hardening of the skin (known as lipohypertrophy), and ensures even absorption over time
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