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Although this could be interpreted as indicating no internalization, it is also consistent with studies that show that GIPR internalizes slowly but rapidly recycles to the cell surface in a constitutive manner (Mohammad et al., 2014)

That would also be heat stress from the sauna or a hot bath or a steam shower or you know, doing things like bikram yoga, yoga routinely again, the aisle 6 and aisle 10, same effect with the, with the sauna