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some preclinical and early research has suggested possible expression in skin-associated cells, though this evidence is not yet well established in humans and should be regarded as hypothesis-generating rather than confirmed
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66 In a randomized, controlled phase 3 study by Jastreboff et al, no difference in gallbladder stone rates was observed between 5, 10, and 15 mg tirzepatide treatment and placebo in obese individuals over 72 weeks
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