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They help the pancreas release insulin when blood sugar is high, work by slowing stomach emptying, and reduce appetite and food intake-which together promote weight loss and improve blood sugar levels
The modest rating volume means it should be treated as early marketplace feedback rather than strong validation
Several peripheral and central mechanisms are believed to be involved, including altered gut hormone secretion, decrease in energy expenditure following weight loss, and psychological processes associated with the food reward system
EMA: While the FDA granted Wegovy an additional indication for CV risk reduction, the EMA did not deem this necessary and only added SELECT data to its label
Together, they produce a stronger, more sustained GH pulse than either peptide alone without spiking cortisol or prolactin, which can actually disrupt sleep
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