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One STEP trial showed an average loss of about 10% with Wegovy versus 3% with placebo over 68 weeks

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Retatrutide appears to have a similar safety profile to other GLP-1 medications: No increased risk of pancreatitis in trials so far No hepatotoxicity signals (liver damage) No cases of ketoacidosis Serious adverse events were rare (2.5% of participants) The trials are ongoing, so we'll learn more about long-term safety

Adults with obesity (BMI 30 ) or overweight (BMI 27 ) with at least one weight-related condition like type 2 diabetes, high blood pressure, or sleep apnea