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Since GSTO1 has been known to cause de-glutathionylation of -actin impeding its polymerization into filamentous actin 11 , such a downregulation of molecules involved in cytoskeleton organization and adhesion is particularly interesting

Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]

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Prospective comparison of medical oncologists and a machine learning model to predict 3-month mortality in patients with metastatic solid tumors

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