However, in diseased kidneys, mitochondrial dysfunction has been reported as a key pathologic feature that contributes to disease initiation and progression.29 30 For example, in diabetic nephropathy (DN), hyperglycemia-induced flux of glycolysis increases oxygen demand with the by-product of amplified ROS.30 31 Excess glucose use in the kidney shifts the energy reliance from fatty acid metabolism to glycolysis, even in the proximal tubules.30 31 The renoprotective effect of SGLT2i in diabetic kidney disease is driven by amelioration of the pathologic metabolic shift from FAO to glycolysis
doi: 10.1210/jc.2010-0490
Dihexa targets a persons cognitive function specifically and produces chemicals that the brain requires to enhance memory
Similarly, the AI-Ready Cross-Scale Transcriptome Integration and Correlation Analysis (ARCTICA) framework demonstrated that combining ML with genome-scale metabolic modeling can identify and manipulate metabolic fluxes, providing a foundation for crop metabolic engineering (Kugler and Stensj, 2024)
Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level
