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In contrast, tirzepatide, an active ingredient of Mounjaro and Zepbound, is a dual agonist of the GLP-1 and GIP receptors

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Under the first phase of the ongoing two part study, the drug demonstrated "statistically significant improvement in liver fibrosis and resolution of steatohepatitis compared to placebo." In August 2025, the company received final approval to market the therapy for the additional indication in the US, followed by a conditional approval in Canada in December