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Studies link it to the hallmarks of extreme dieting: caloric deficits that cause iron, protein, zinc, and biotin shortages and hormonal shifts like elevated cortisol levels and/or insulin fluctuations

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doi:10.1016/B978-0-12-385114-7.00018-0 Butturini E, Carcereri de Prati A, Chiavegato G, Rigo A, Cavalieri E, Darra E, Mariotto S (2013) Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs