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There is no trial data mandating a specific time of day, but the STEP 5 long-term extension noted that most GI events occurred early in each dose-escalation phase, supporting the logic of extra dietary caution in the 48-hour post-injection window
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A gradient shallow enough to resolve positional isomers, or peptide mapping after enzymatic digestion, speaks to this question
In some cases, some vomiting or other GI issues might occur
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