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(2024, Frontiers in Bioengineering and Biotechnology ) reviewed multiple dissolving microneedle systems for anti-obesity molecules and noted the technology's promise for overcoming the permeability barrier that blocks passive transdermal delivery of peptides
Body fat converts androgens to estrogens through aromatase, contributing significantly to total estrogen exposure, particularly in postmenopausal women but also in premenopausal women with excess adipose tissue
Functionally, impaired intestinal barrier integrity leads to increased translocation of microbe-associated molecular patterns (MAMPs) into the portal circulation 78
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