These medicines, including liraglutide, albiglutide, dulaglutide, and semaglutide, were synthesised using strategic changes of the human GLP-1 molecule to diminish its vulnerability to DPP-4 breakdown
It is typically reversible with dose reduction but should not be ignored
Especially if youre vegetarian or vegan, on certain medications (like metformin or antacids), have gut issues, or are simply burned out from lifeits likely that youre low
However, endogenous GLP-1 has a short half-life ( t = 23 min) and is therefore not well suited for the treatment of T2DM [11]
The GLP-1 peptide (a short chain of amino acids) is secreted by cells in the small intestine, but it is also synthesized in the brain