Although direct targeting of RIPK1 and RIPK3 is limited due to their roles in normal cellular processes, the mitochondrial protein Smac can inhibit inhibitor of apoptosis proteins (IAPs), thereby enabling RIPK1 and RIPK3 activation and promoting necroptosis [327,328,329,330]
A There are three possible causes 1
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World J Gastroenterol 12(27):43454351 Aboulthana WM, Ibrahim NE, Hussien AG, Hassan AK, Khalil WKB, Abdel-Gawad H, Taha HA, Kelany AK, Ahmed KA (2025) Assessment of the gold nanoparticles biosynthesized using Casuarina equisetifolia bark extract against the ethion induced hepato- and neurotoxicity in rats