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For anyone taking other medications, trying to cram their pills into a busy morning or with an unpredictable eating schedule, injection may be best or orforglipron
Most patients tolerate both therapies well when administered under clinical supervision
However, as discussed in the next sections of this paper, we cannot exclude that maternal polymorphisms of folate pathway genes, their preferential transmission to a DS embryo, as well as epigenetic modifications and expression levels of folate-related genes mapping to chromosome 21, could contribute to the DS phenotype, including the development of congenital defects or that of other diseases later in life
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