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That's because B12 binds to protein and, as the body ages, stomach acid decreases
J Cereb Blood Flow Metab 40(3):461481 Wu M-T, Ye W-T, Wang Y-C, Chen P-M, Liu J-Y, Tai C-K et al (2021) MTHFR knockdown assists cell defense against folate depletion induced chromosome segregation and uracil misincorporation in DNA
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The peak fractions (excluding those partially overlapping with the void volume peak) of the SEC-purified complex were pooled and concentrated to 6 mg ml 1
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