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The SURMOUNT-4 trial showed even steeper rebounds with tirzepatide, with participants regaining more than 50% of their weight loss over 52 weeks after stopping
The EXSCEL (NCT01144338), HARMONY (NCT02465515), REWIND ( NCT01394952), and AMPLITUDE-O (NCT03496298) trials all demonstrated cardioprotection or near misses for exenatide, albiglutide, dulaglutide and efpeglenatide, respectively
however, new technologies like chemical modifications (e.g., cyclic peptides), nanoparticles, and specific absorption enhancers (like SNAC in Ozempic's oral version, Rybelsus) are making oral delivery possible for certain therapeutic peptides, like semaglutide (Wegovy/Ozempic), transforming them from injections to convenient tablets, though many supplements lack strong evidence
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