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Clinical Considerations Disease-associated maternal and/or embryofetal risk Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery, and delivery complications
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This is partly because the body's weight set point defends against the lower weight, and partly because GLP-1 receptors in the brain that were being continuously stimulated are no longer activated
10.1080/13510002.2021.1952819 Redox Rep
6.0%), and 20% (14.3% vs 1.7%).The STEP 8 trial [157] (ClinicalTrials.gov identifier: NCT04074161) was a 68-week, randomized, placebo-controlled trial of either once-weekly semaglutide 2.4 mg, or once-daily liraglutide 3.0 mg, or placebo in adults with obesity or overweight with type 2 diabetes
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