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The Bottom Line If you require a Phase III randomized controlled trial before you'll consider any treatment, the only options for hair loss are still minoxidil and 5-AR inhibitors

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The key features that distinguish paraptosis from classical apoptosis include its independence from caspase-9 activation, the absence of typical apoptotic markers such as chromatin condensation or DNA laddering, and cytoplasmic vacuolisation as the predominant morphological feature positively modulated by the mitogen-activated protein kinase (MAPK) signalling pathway [119]

Similarly, there is risk in most studies of underreporting PDAC events due to ascertainment bias, because active surveillance is not typically performed in controlled trials or performed in routine clinical practice

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