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Fifth, previous CVOTs have suggested that the beneficial effects of GLP-1 RAs are primarily associated with long-acting agents such as liraglutide, semaglutide, and dulaglutide, rather than short-acting agents like exenatide and lixisenatide [17, 54, 56, 57, 68]
The caloric deficit that produced rapid initial losses now barely moves the needle
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Although DPP4i extends the half-life of endogenous GLP-1, its effectiveness is significantly less than the supraphysiologic effects of GLP-1 receptor agonists
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