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Li H, Wei Y, Wang J, Yao J, Zhang C, Yu C, et al

45 Interestingly, a study also shows that NADPH level is not changed by silencing PGD expression, which is possible that a temporally increased NADP + /NADPH ratio compensatory increased G6PD activity, thus generating NADPH

This physiological mechanism, which is useful for the post-translational modification of multiple proteins and for the regulation of signal and metabolic pathways, can turn harmful in case of oxidative stress, with the above-mentioned mitochondrial damage

(PubMed) Li X, Hill KE, Burk RF, May JM