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Merck has built a patent estate around pembrolizumab that includes composition-of-matter patents on the antibody structure, method-of-use patents covering its approved indications (pembrolizumab has over 40 FDA-approved indications and indication-specific dosing regimens), and formulation patents on its IV formulation and concentration

Even something as seemingly simple as incorrect dosing calculations can skew your results so dramatically that your data becomes meaningless

Mounted on the membrane-facing surface of the cytoplasmic tip of TM6, compound 2 was able to induce a newly discovered ECD conformation allowing its N-terminal helix to penetrate into the TMD core, a key step for the ago-allosterism observed experimentally, consistent with the intrinsic agonism hypothesis for the ECD of GLP-1R 40

Washington: Patent and Trademark Office

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