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At the cellular level, chronic hyperglycemia initiates several pathogenic mechanisms

Peer-reviewed microbiome research highlights that: Microbial composition determines the production of short-chain fatty acids, neurotransmitter precursors, bile acid metabolites, and inflammatory mediators

Yet many people with obesity may not seek out semaglutide, and doctors may not prescribe it to them not only because of the dangerous history of weight loss medications, but also because of a persistent bias and stigma around a disease that now afflicts nearly half of Americans

In some cases, they may prescribe nonhormonal medication or hormone therapy to treat hot flashes

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