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Tirzepatide may reduce the effectiveness of oral contraceptives due to delayed gastric emptying, making backup contraception important during dose changes (Eli Lilly and Company, 2024)

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Notably, several stable cell linesincluding HEK293T-Arrestin2-hCTR, HEK293T-Arrestin2-hAMY1R, HEK293T-Arrestin2-hAMY2R, and HEK293T-Arrestin2-hAMY3Rhave been generated and optimized using reference compounds such as sCT, human calcitonin, and rat amylin