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The liver is particularly susceptible to oxidative stress due to its central role in metabolizing various substances, including drugs and alcohol
Renal dysfunction
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Two types of medications for ulcers and gastric reflux proton-pump inhibitors, such as omeprazole (Prilosec) and lansoprazole (Prevacid), and H2 blockers like cimetidine (Tagamet), famotidine (Pepcid), and ranitidine (Zantac) inhibit the release of stomach acid necessary to free dietary vitamin B12
clinicians should monitor for gastrointestinal cramping or bradycardia in co-treated patients
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