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For example, previous studies have shown that APP/PS1 transgenic mice that express the mutated variant of human APP and PSEN1 genes linked to familial AD, namely, the Swedish APP KM670/671NL mutation (APPswe) and PSEN1 L166P mutation, exhibit memory deficits and impaired hippocampal neurogenesis in adulthood [124]

Conversely, men have higher risk of inflammation or tissue damage due to higher amount of cytokines and chemokines like IL-2, TNF, IL-7, IL10, IL-18, CCL14, or CCL23 (144)

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