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However, its use requires daily injections, is associated with a significant risk of hypoglycaemia, and exerts anabolic effects that, particularly when combined with GCs therapy, may lead to progressive weight gain

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This is evident from studies where exenatide blunted the fMRI signal in brain areas such as the amygdala, insula, hippocampus, and frontal cortex in obese individuals but not in lean individuals [16, 17]

Both conditions involve the gastrointestinal system, and semaglutide's mechanism of slowing gastric emptying and its gastrointestinal side effect profile may have implications for individuals with pre-existing inflammatory bowel disease

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