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Nannipieri M, Baldi S, Mari A, Colligiani D, Guarino D, Camastra S, et al

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Genetic mutation leading to abnormal hemoglobin production Polymerization of hemoglobin S under low oxygen conditions Increased adhesion of sickled red blood cells to the vascular endothelium Inflammation and endothelial dysfunction contributing to vaso-occlusive events Understanding these factors is vital for effective SCD management strategies