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HIF-1 primarily regulates glycolytic metabolism and acute hypoxic responses, while HIF-2 is more involved in chronic hypoxia, tumor proliferation, and stemness

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After at least two years of treatment, GLP-1 users had a 37 percent higher chance of developing alopecia than patients taking SGLT-2 drugs and 68 percent higher odds than those taking DPP-4 drugs, both of which are also used to treat type 2 diabetes