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Los grupos tiol se mantienen en un estado reducido a una concentracin de aproximadamente ~ 5 mM en clulas animales

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However, research on liraglutide, including a 31-study meta-analysis of over 8,000 patients, has shown that injection of GLP-1 agonists stimulates the same effect on the vagus nerve whether stomach tissue is distended or not

Notably, GLP-1 signaling interacts with the mesolimbic dopaminergic system, suggesting a potential role in modulating addictive behaviors