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It is a peptide in the strict biochemical sense: a chain of amino acids designed to mimic and amplify the action of GLP-1, a hormone the gut naturally releases after eating
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doi: 10.2174/1381612824666180712110447
The optimized analog, compound 32 ((4S,5S)-5-(aminomethyl)-1-(2-(benzo[d] [1,3] dioxol-5-yl) ethyl)-4-(2,5-difluorophenyl) piperidin-2-one), was found to exhibit high levels of DPP-4 selectivity and potency in vitro
Increased MDA levels and decreased serum SOD levels enhance the serum levels of TNF- and IL-6 during DENV-2 infection 126
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